Stelzer G., Rosen N., Plaschkes I., Zimmerman S., Twik M., Fishilevich S., Stein T.I., Nudel R., Lieder I., Mazor Y., et al.
GeneCards Version 3: the human gene integrator. Safran M., Dalah I., Alexander J., Rosen N., Iny Stein T., Shmoish M., Nativ N., Bahir I., Doniger T., Krug H., et al. MalaCards: an integrated compendium for diseases and their annotation. Rappaport N., Nativ N., Stelzer G., Twik M., Guan-Golan Y., Stein T.I., Bahir I., Belinky F., Morrey C.P., Safran M., et al. Thorburn, Johan Van Hove, Lynne Wolfe, and Lee-Jun Wong. Smeitink, Christine Stanley, Anu Suomalainen, Mark Tarnopolsky, Isabelle Thiffault, David R. Shoubridge, Domenico Simone, Bert Smeets, Jan A. Pierce, Vincent Procaccio, Shamima Rahman, Honey Reddi, Heidi Rehm, Erin Riggs, Richard Rodenburg, Yaffa Rubinstein, Russell Saneto, Mariangela Santorsola, Curt Scharfe, Claire Sheldon, Eric A. Mootha, Yasushi Okazaki, Aurora Pujol, Melissa Parisi, Juan Carlos Perin, Eric A.
Haas, Hakon Hakonarson, Michio Hirano, Douglas Kerr, Dong Li, Maria Lvova, Finley Macrae, Donna Maglott, Elizabeth McCormick, Grant Mitchell, Vamsi K. den Dunnen, David Dimmock, Gregory Enns, Giuseppe Gasparre, Amy Goldstein, Iris Gonzalez, Katrina Gwinn, Sihoun Hahn, Richard H. Cotton, IFM de Coo, Olga Derbenevoa, Johan T. Published by Oxford University Press on behalf of Nucleic Acids Research.įalk MJ, Shen L, Gonzalez M, Leipzig J, Lott MT, Stassen AP, Diroma MA, Navarro-Gomez D, Yeske P, Bai R, Boles RG, Brilhante V, Ralph D, DaRe JT, Shelton R, Terry SF, Zhang Z, Copeland WC, van Oven M, Prokisch H, Wallace DC, Attimonelli M, Krotoski D, Zuchner S, Gai X MSeqDR Consortium Participants MSeqDR Consortium participants: Sherri Bale, Jirair Bedoyan, Doron Behar, Penelope Bonnen, Lisa Brooks, Claudia Calabrese, Sarah Calvo, Patrick Chinnery, John Christodoulou, Deanna Church, Rosanna Clima, Bruce H. International Classification of Diseases, Human Phenotype Ontology and Unified Medical Language System) and also contains information about multi-level relations among diseases, thereby providing an optimal tool for disease representation and scrutiny. MalaCards adopts a 'flat' disease-card approach, but each card is mapped to popular hierarchical ontologies (e.g. MalaCards' capacity to inter-link information from complementary sources, along with its elaborate search function, relational database infrastructure and convenient data dumps, allows it to tackle its rich disease annotation landscape, and facilitates systems analyses and genome sequence interpretation. This is accompanied by other gene-related disease information such as pathways, mouse phenotypes and GO-terms, stemming from MalaCards' affiliation with the GeneCards Suite of databases. A central feature is a balanced Genes section, with scores reflecting the strength of disease-gene associations. The Aliases and Classifications section reflects an algorithm for disease name integration across often-conflicting sources, providing effective annotation consolidation. It portrays a broad array of annotation topics in 15 sections, including Summaries, Symptoms, Anatomical Context, Drugs, Genetic Tests, Variations and Publications. MalaCards has a web card for each of ∼20 000 disease entries, in six global categories. The MalaCards human disease database () is an integrated compendium of annotated diseases mined from 68 data sources.